Sly Represses Gene Expression in Sex Chromosomes
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چکیده
منابع مشابه
Sly Represses Gene Expression in Sex Chromosomes
The nuclei of eukaryotic cells can be thought of as a library containing the molecular ‘‘recipes,’’ or genes, for constructing the proteins and ribonucleic acid molecules used by a cell. Within the library, genes are grouped together into ‘‘books,’’ known as chromosomes, which consist of linear strands of DNA wrapped around specialized DNA-interacting proteins. Human body cells have 46 chromoso...
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Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR). Several genes have been identified on MSYq, but because they are present in more than 40 copies each, their functions cannot be investigated using traditional gene targeting. Here, we generate...
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Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and one Y. Fusions of sex chromosomes with autosomes have occurred along the lineage leading to D. pseudoobscura and D. miranda. The resulting neo-s...
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Background When gonadal sex reversal occurs in mammalian species, the resultant XX males and XY females become infertile or subfertile, suggesting critical roles of sex chromosomes in germ cell differentiation. The objective of our study is to clarify the mechanism of infertility in the B6.YTIR (XY) sex-reversed female mouse, which can be attributed to a failure in the second meiotic division i...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2009
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000243